BMJ Open Diabetes Res Care. 2016 Feb 10;4(1):e000148. doi: 10.1136/bmjdrc-2015-000148. eCollection 2016.
Vitamin D for the treatment of painful diabetic neuropathy.
Basit A1, Basit KA2, Fawwad A1, Shaheen F2, Fatima N2, Petropoulos IN3, Alam U4, Malik RA5.
To assess the effect of high-dose vitamin D in patients with painful diabetic neuropathy.
A single intramuscular dose of 600 000 IU vitamin D was administered, and the effects on metabolic parameters and neuropathic pain assessed over 20 weeks.
143 participants with predominantly type 2 diabetes, aged 52.31±11.48 years, with a Douleur Neuropathique 4 (DN4) score (3.0±1.8), total McGill pain score (21.2±14.9), and Short Form McGill Pain Questionnaire (SFMPQ) score (2.1±0.9), were enrolled. The baseline 25-hydroxyvitamin D (25(OH)D) level was 31.7±23.3 ng/mL and 58 (40.5%) patients showed evidence of vitamin D deficiency (25(OH)D<20 ng/mL). Intramuscular administration of vitamin D resulted in a significant increase in 25(OH)D (46.2±10.2 ng/mL, p<0.0001) and a reduction in positive symptoms on the DN4 (p<0.0001), total pain score (p<0.0001), and SFMPQ (p<0.0001).
Treatment with a single intramuscular dose of 600 000 IU of vitamin D in patients with painful diabetic neuropathy is associated with a significant decrease in the symptoms of painful diabetic neuropathy.
TRIAL REGISTRATION NUMBER:
Neuropathy Complications; Neuropathy and Clinical Diabetes; Pain; Vitamin D
Jeff T Bowles: Being the author of the best-selling book on Vitamin D3 in the world, and given the topic of the book was the miraculous results of my one year experiment of taking HIGH DOSES of vitamin D3, puts me in the unique position of being the sounding board for many hundreds if not a few thousands of others who have embarked on their own high dose vitamin d3 experiment. Nobody on planet earth has this amount of unusual and exciting knowledge, and I will be sharing it with you in this series of 100 short articles describing a disease and some sort of amazing result achieved with high dose D3 therapy.
Sincerely Jeff T. Bowles